5-Fluorinated L-lysine analogues as selective induced nitric oxide synthase inhibitors

E Ann Hallinan; Timothy J Hagen; Arija Bergmanis; William M Moore; Gina M Jerome; Dale P Spangler; Anna M Stevens; Huey S Shieh; Pamela T Manning; Barnett S Pitzele

doi:10.1021/jm030348f

5-Fluorinated L-lysine analogues as selective induced nitric oxide synthase inhibitors

J Med Chem. 2004 Feb 12;47(4):900-6. doi: 10.1021/jm030348f.

Authors

E Ann Hallinan¹, Timothy J Hagen, Arija Bergmanis, William M Moore, Gina M Jerome, Dale P Spangler, Anna M Stevens, Huey S Shieh, Pamela T Manning, Barnett S Pitzele

Affiliation

¹ Pfizer, 4901 Searle Parkway, Skokie, Illinois 60077, USA. eahallinan@comcast.net

PMID: 14761191
DOI: 10.1021/jm030348f

Abstract

5(S)-Fluoro-N6-(iminoethyl)-l-lysine (14), an analogue of the potent, selective induced nitric oxide synthase (iNOS) inhibitor iminoethyl-l-lysine (1), was synthesized and found to be a selective iNOS inhibitor.

MeSH terms

Crystallography, X-Ray
Isoenzymes / antagonists & inhibitors
Isoenzymes / chemistry
Lysine / analogs & derivatives
Lysine / chemical synthesis*
Lysine / chemistry
Models, Molecular
Nitric Oxide Synthase / antagonists & inhibitors*
Nitric Oxide Synthase / chemistry
Nitric Oxide Synthase Type II

Substances

5-fluoro-N6-(iminoethyl)lysine
Isoenzymes
Nitric Oxide Synthase
Nitric Oxide Synthase Type II
Lysine